abstract |
The present invention provides compounds of formula Ia-1 possessing β-secretase 1 inhibitor (BACE1) activity, preparation thereof, pharmaceutical compositions containing such compounds, and their use as therapeutically active substances for treating and / or preventing diseases and disorders characterized by an elevated β level. α-amyloid, and / or β-amyloid oligomers, and / or β-amyloid plaques and other deposits, such as Alzheimer's disease. |