| abstract |
A compound is claimed that can be used as a prophylactic and / or therapeutic agent for bladder cancer. As a result of studies of compounds possessing inhibitory activity against FGFR, it was found that the nitrogen-containing aromatic heterocyclic compounds of formula (I), where R, Q, L, X, Y, Z, W and p are as defined in the claims, have inhibitory activity against FGFR1, FGFR2 and / or FGFR3, in particular against mutant FGFR3, and thus the present invention has been made. Nitrogen-containing aromatic heterocyclic compounds of the present invention can be used as a therapeutic agent for various types of malignant tumors associated with FGFR1, FGFR2 and / or FGFR3, such as lung cancer and hormone-resistant breast cancer, stomach cancer, triple negative breast cancer and endometrial cancer, bladder cancer and glioblastoma, in particular as a prophylactic and / or therapeutic agent for bladder cancer positive for the FGFR3 mutation. |