| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df6a70142a91018f2990857aca3f346c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1688
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1617
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-30 |
| filingDate |
2004-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c8951b6c22b814651548b0953dd5065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_776c37327141c4a5b459d09475771608 |
| publicationDate |
2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-026709-B1 |
| titleOfInvention |
METHOD OF OBTAINING COMPOSITION OF ESTRADIOL WITH SLOW-OFF-FREEDOM (OPTIONS) |
| abstract |
The invention relates to a method for producing a slow-release estradiol composition comprising (a) preparing particles consisting of 17-β-estradiol and cholesterol in a 1: 1 ratio between 17-β-estradiol and cholesterol, where each of them is in amorphous or polymorphic form; (b) exposure of the atmosphere to the particles from step (a) at a relative humidity of 25% or less for 24 hours; (c) exposure of an atmosphere saturated with acetone and water to the particles from step (b) for 72 hours at 60 ° C; (d) heating the particles from step (c) at 45 ° C for 42 hours, while the dissolution rate of 17-β-estradiol (SRE) from the particles obtained in step (d) is less than 6% when measured in water a solution of 0.3% wt./about. polyoxyethylene sorbitan monooleate (Tween80®) and water purified according to USP for 24 hours at 37 ° C and standard pressure. The composition of slow release, obtained by the method according to the present invention, gives dual advantages to the composition with a low dose of estradiol with a low-frequency administration scheme. The composition may be administered parenterally once a month or at a lower frequency. |
| priorityDate |
2003-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |