| abstract |
The invention provides a pharmaceutical composition comprising at least one CRTH2 antagonist and at least one proton pump inhibitor selected from the group consisting of omeprazole, esomeprazole, lansoprazole, dexlansoprazole, pantoprazole and rabeprazole or their pharmaceutically acceptable salts, where said CRTH2 antagonist is is a compound of the general formula (I) where these substituents are defined in the claims, or a pharmaceutically acceptable salt thereof. In addition, the proposed kit for the treatment of eosinophilic esophagitis (EoE), containing the specified composition, and a method of preventing, treating or alleviating EoE in an individual, comprising administering to the individual a therapeutically effective amount of the specified composition. Also described is the use of this composition to obtain an agent for preventing, treating or alleviating EoE. |