| abstract |
The invention provides compounds of the general formula (Id) where Z, -Z-EWG-, R, R, R, R and R are as defined in the invention, and their pharmaceutically acceptable salts, which are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK and TXK are, therefore, useful for treating diseases that can be treated by inhibiting tyrosine kinases, such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and their pharmaceutically acceptable salts, and methods for producing such compounds and their pharmaceutically acceptable salts, as well as their use for the manufacture of a medicament for the treatment of inflammatory diseases, autoimmune diseases or cancer. |