abstract |
The present invention proposed difluoro-cyclopentaoxazinyls and difluoro-benzooxazinyls of formula I, which have inhibitory activity against beta-secretase 1 (BACE1 from the English "beta-secretase 1"), their preparation, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in therapeutic and / or prophylactic treatment, for example, Alzheimer's disease. |