| abstract |
The invention relates to a biosynthetic irregular helical polypeptide, or to a segment of biosynthetic irregular detectors, or to a biosynthetic conjugate, where the specified biosynthetic irregular helical polypeptide, the specified segment of the biosynthetic irregular helical polypeptide or the specified biosynthetic core, or a biosynthetic polypeptide, a specified segment of the biosynthetic irregular helical polypeptide or a biosynthetic conjugate junction, or a biosynthetic elongated junction polypeptide, a biosynthetic irregular helical polypeptide segment or a biosynthetic junction polypeptide, or a biosynthetic polypeptide core, or where specified amino acid follower The content consists of at least about 50 amino acid residues of proline (Pro) and alanine (Ala). Said at least about 50 amino acid residues of proline (Pro) and alanine (Ala) can be part of the heterologous polypeptide or heterologous polypeptide construct. Also described are the uses and methods of using these biosynthetic irregular helical polypeptides, either segments or conjugates of these polypeptides. These applications may include, among others, medical applications, diagnostic applications or applications in the food industry, as well as other industrial applications, for example in the paper industry, in oil production, etc. In particular, a drug conjugate that contains (1) a biosynthetic irregular helical polypeptide or polypeptide segment containing an amino acid sequence consisting solely of the amino acid residues of proline and alanine, wherein said amino acid sequence consists of at least about 50 amino acid residues of proline (Pro ) and |