| abstract |
The invention relates generally to compounds and pharmaceutical compositions selectively activating Toll-like receptor 7 (TLR7), and methods for their preparation and use. A compound of formula II is provided, wherein R <1> is -NRR; R2 is C-C-alkyl, C-C-alkenyl, C-C-carbocyclyl-C-C-alkyl or phenyl-C-C-alkyl, possibly containing as a substituent on the phenyl ring C-C-alkoxy; -L-R1 is -O-C-C-alkyl or -O-C-C-alkylene-O-C-C-alkyl; each of R 8 and R 10 is independently H or C — C-carbocyclyl-C — C-alkyl; or R and R together with the nitrogen to which they are both attached, form an unsubstituted heterocycle, with the said heterocycle being a 4-6 membered monocyclic fully saturated ring containing a heteroatom selected from N; and n is 0, and the pharmaceutically acceptable salts of said compound, compositions containing said compound or a salt thereof, methods of providing agonistic effects on Toll-like receptor 7, which include the use of such compounds, as well as the use of said compound as a therapeutic substance. |