| abstract |
The invention relates to new kinase inhibitors, namely, ROCK inhibitors of formula I, where all the substituents are disclosed in the claims, compositions, in particular, pharmaceutical preparations containing such inhibitors, and to the use of such inhibitors in the treatment and prevention of diseases. In particular, the present invention relates to new inhibitors of ROCK, to compositions, in particular pharmaceutical preparations containing such inhibitors, and to the use of such inhibitors in the treatment and prevention of diseases. In addition, the present invention relates to methods of treatment and the use of these compounds in the manufacture of a medicinal product for use in a number of therapeutic indications, including eye diseases, respiratory diseases and intestinal diseases. The structural formula I |