abstract |
The invention relates to pharmaceuticals. The method includes the preparation of an emulsion of oxaliplatin and a lipid film based on phospholipid and cholesterol, their mixing, homogenization at least in two cycles, filtration, ultrafiltration, sterilization and lyophilization. The achieved result consists in the standardization and stability of the obtained preparation of liposomes (the size of liposomes is presented in a narrow range) containing oxaliplatin, high encapsulation of oxaliplatin in liposomes, stability of the product during storage. |