abstract |
The invention describes a process for the preparation of tert-butyl-6-chloro-3,5-dioxohexanoate from a Meldrum acid derivative and its use in the preparation of tert-butyl (4R, 6S) - (6-hydroxymethyl-2,2-dimethyl-1, 3-dioxan-4-yl) acetate (BHA), Rosuvastatin and atorvastatin. |