http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-023360-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7993f3941238bbeb7b25ce1964fd0eed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a723ff85f5b1cd7468c68d34c1d7c426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59cb995a289b3e4dced00910a5ad3d45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ff15ccc126b20fd06e4a06357f330da |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2013-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7af7e4908b106a4a741d0ca2605f4a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af93e04d5c059f01e23aa4e606454fe3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03a6f30a013489bf70d7a308919c5894 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d583a3a5daff65c6057c6e9ccc6bb31a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51ecac778461fe29aebf6af86ece73fc |
| publicationDate | 2016-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-023360-B1 |
| titleOfInvention | LINEAR ACYLASIDE PEGYLING AGENT, METHOD FOR ITS OBTAINING AND METHOD FOR OBTAINING PEGYLED INTERFERON |
| abstract | The invention relates to the pharmaceutical industry, in particular to a pegylating agent capable of joining free amino groups of proteins to form an amide bond through an azide condensation reaction, as well as a method for producing it and a method for tahilating biologically active proteins, for example, interferons. The invention provides methods for producing a linear acyl azide pegylating agent and corresponding methods for pegylating interferons (IFN), in particular IFN α-2b. The technical result of the invention is a pegylating agent - a derivative of PEG-phenylalanine, capable of joining free amino groups of proteins with the formation of an amide bond through azide condensation without causing racemization of the substrate, which can be easily identified in the UV region from the aromatic fragment and quantified. |
| priorityDate | 2013-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 242.