| abstract |
The invention relates to a new derivative of isoquinoline-6-sulfonamide, which is suitable as a drug for the treatment and / or prevention of glaucoma, ocular hypertension and cardiovascular disease. The present invention relates to an isoquinoline-6-sulfonamide derivative according to formula (1), a salt thereof or a solvate of a derivative or salt, wherein each of R1 and R3 independently represents a hydrogen atom or the like; each of R2 and R3 independently represents a hydrogen atom, an alkyl group or the like; R 4 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, or the like; and A represents a linear or branched alkylene group having from 2 to 6 carbon atoms. |