| abstract |
The invention relates to new heterocyclic derivatives of formula (I) as glutaminyl cyclase inhibitors (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of the N-terminal glutamine residues to form pyroglutamic acid (5-oxoprolyl, pGlu *) with the release of ammonia in the free state, and the intramolecular cyclization of the N-terminal glutamate residues with the formation of free pyroglutamic acid in the free state of water. |