http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-021117-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cabf989322e4e0af9806d2bccec0fb25 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82B3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 |
| filingDate | 2010-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd57f126847819207eab0143b47fd325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebb05a2818294fff0d014ed080f3f2ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a520cc654a2efc3a6ea742acbd93be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77bdd45d897273bec48994b04ef25f8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bebdf06e87816fe29c856098d3c88c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85c4fbe27ec5e261e9220fd357b6df28 |
| publicationDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-021117-B1 |
| titleOfInvention | A method for producing a water-soluble pharmaceutical composition of an antibiotic from a group of RIFAMYCINES and a pharmaceutical composition for treating tuberculosis and diseases associated with a heliobobter pyllose |
| abstract | The invention relates to pharmaceuticals, more specifically, to anti-TB drugs and methods for their preparation. In accordance with the present invention, a method for producing a water-soluble pharmaceutical composition of an antibiotic from a group of rifamycins in the form of a powder is provided, comprising: a) dissolving an antibiotic from a group of rifamycins in an organic solvent selected from the group consisting of ethanol, isopropanol and acetone, b) adding a solution obtained at the stage a) dropwise to an aqueous solution of albumin obtained by dissolving 1-10% m / v albumin in sterilized demineralized water, c) mixing the resulting mixture, d) filter tion, d) adding a cryoprotectant selected from the group consisting of mannitol and trehalose, e) freezing, f) drying (freeze-or spray). Also provided is a pharmaceutical composition for treating tuberculosis and diseases caused by persistence in the patient’s body of Helicobacter pylori, containing an antibiotic powder from the rifamycin group, obtained by the method according to any one of claims 1, 2, which forms, when added, a pharmaceutically acceptable diluent and / or carrier suitable for intravenous administration in need of this patient a stable suspension, characterized in that said powder and said suspension, which is formed from it by the addition of a pharmaceutical cally acceptable diluent and / or carrier, characterized by an average particle size of 100 to 800 nm, and upon dilution 100 times - from 5 to 80 nm. The technical result is the elimination of trace amounts of methylene chloride, the simplification of the technology for obtaining the dosage form. |
| priorityDate | 2010-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.