| abstract |
The invention provides a method for producing 2,3,4,5-tetrahydro [1,4] benzothiazepine of the formula by reacting [2- (acylaminoethyl) thio] arene of the formula with an aldehyde or its multimer and with an acid. The invention also provides a method comprising first reacting [2- (acylaminoethyl) thio] arene with an aldehyde or its multimer and base to form [N-hydroxymethyl-2- (acylaminoethyl) thio] arena of the formula and then treating [N-hydroxymethyl-2- ( acylaminoethyl) thio] arene acid with the formation of 2,3,4,5-tetrahydro [1,4] benzothiazepine. |