| abstract |
The invention provides N - ((1R, 2S, 5R) -5- (tert-butylamino) -2 - ((S) -3- (7-tert-butylpyrazolo [1,5-a] [1,3,5 ] triazin-4-ylamino) -2-oxopyrrolidin-1-yl) cyclohexyl) acetamide: and its crystalline form N1, having double inhibitory activity against the receptors CCR-2 and CCR-5. Disclosed are compositions based on these compounds and the use of compounds and compositions for modulating the activity of CCR-2 and CCR-5 receptors and for treating inflammatory, allergic, autoimmune, metabolic, cancerous and / or cardiovascular diseases. The invention also provides a method for producing N - ((1R, 2S, 5R) -5- (tert-butylamino) -2 - ((S) -3- (7-tert-butylpyrazolo [1,5-a] [1, 3,5] triazin-4-ylamino) -2-oxopyrrolidin-1-yl) cyclohexyl) acetamide. |