| abstract |
The present invention relates to monoclonal antibodies and their antigen-binding fragments that bind to human FPN1 and inhibits its activity, which is effective in maintaining or enhancing the transport of iron from mammalian cells and / or maintaining or increasing the concentration of iron in serum, the number of reticulocytes, the number of red blood cells, hemoglobin and / or hematocrit in the body of an individual in vivo. |