| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b97d4f6f618c15f9ce7dd420b4cb135b |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G73-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-53 |
| filingDate |
2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3abf85e66245390dc7b8734c57b9a05a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e63df5b4acfb633f7decfaa44f27f80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2472b7e1ebbed7e89243d05a0c9c2491
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d12ac4d0da49b17346833c6422ee2929
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a65235fb009362b9be1302d5cf27f05 |
| publicationDate |
2014-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-020425-B1 |
| titleOfInvention |
COVALENT CONJUGATE OF POLYETHYLENE GLYCOL WITH GRANULOCITARIAN COLONIUS STIMULATING FACTOR OF THE PERSON |
| abstract |
The invention relates to medicine and biotechnology and relates to the covalent conjugate of polyethylene glycol with a granulocyte colony-stimulating factor of a person, in which PEG is attached to the tyrosine or histidine fragments of a polypeptide through an azo group of general structure: where n is an integer in the range from 100 to 1200; A - amino acid fragment of tyrosine or histidine; G-CSF - granulocyte colony-stimulating factor. The G-CSF conjugate has a longer circulation time in the bloodstream compared with the unmodified polypeptide, while maintaining a significant proportion of its activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2749509-C1 |
| priorityDate |
2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |