| abstract |
The present invention relates to intermediate compounds for the preparation of agomelatine, as well as to methods for their preparation. The intermediate compound of the present invention for the preparation of agomelatine is compound A according to the following formula. Two new intermediates are also provided. When these new intermediates are used to produce agomelatine, the method is simple to control, well controlled and gives a product with high purity, without complicated operations, such as rectification and separation by column chromatography, and is suitable for industrial production. However, the methods for producing the two new intermediate compounds themselves are simple and in high yield only when the most widely used 7-methoxytetralone is used as the starting starting material and one reaction step is carried out to produce the intermediate compounds, followed by another step of converting the intermediate compound to the desired product. agomelatine. The above reaction processes are very simplified, with an improved yield of reaction, and also overcome the difficulties in cleaning the previous method when compared with the previous method of obtaining agomelatine. Typically, the yield of the present invention is in excess of 70%. |