| abstract |
The invention relates to new compounds corresponding to formula III, in which the definitions of B, X, X, X, X, X, E and L are given in the description; the compounds of the present invention are positive allosteric modulators (enhancers) of subtype B gamma-aminobutyric acid receptors ("GABA"), which can be used in methods of treating or preventing diseases or disorders, including the treatment of anxiety, depression, epilepsy, schizophrenia, cognitive impairment, spasticity and rigidity of skeletal muscle, damage to the spinal cord, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic other pains and addiction to cocaine and nicotine, panic disorder, post-traumatic stress disorders, urgent urinary incontinence, gastroesophageal reflux disease, temporary relaxation of the lower esophageal sphincter, functional gastrointestinal disturbances and irritable bowel syndrome. |