| abstract |
The invention provides a description of compounds forming covalent bonds with Bruton's tyrosine kinase (Btk) and irreversible Btk inhibitors. Methods for the preparation of such compounds are described, as well as pharmaceutical compositions containing such compounds. In addition, a description is given of methods for using Btk inhibitors alone or in combination with other therapeutic agents to treat autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. |