http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-019319-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b97d4f6f618c15f9ce7dd420b4cb135b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2011-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2472b7e1ebbed7e89243d05a0c9c2491 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e63df5b4acfb633f7decfaa44f27f80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a65235fb009362b9be1302d5cf27f05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_055c7510f6898b3383598df6fadea640 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a88ee8e255282829c0f725a20acd182a |
| publicationDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-019319-B1 |
| titleOfInvention | Method of producing covalent conjugate of polyethylene glycol with an interferon and method of producing an activated peg-agent |
| abstract | The invention relates to a method for producing a covalent polyethylene glycol conjugate with interferon, characterized in that a) a free hydroxyl group of monomethoxy polyethylene glycol is acylated with nitrobenzoic acid halide in a halogenated organic solvent in the presence of an organic base; b) the nitro group of the nitrobenzoic acid methoxy polyethylene glycol ester obtained is reduced with a salt of the d-element 4 of the period IV-VI group to a low degree in an aqueous or aqueous-organic medium with a pH from 1.0 to 6.5 or in a polar organic solvent; c) aminobenzoic acid methoxypolyethyleneglycol ether obtained is diazotized with alkali or alkaline earth metal nitrite in an aqueous or aqueous-organic medium or organic nitrite in a polar organic solvent medium, followed by removal of excess nitrite and obtaining an activated pegylating agent; d) the activated pegylating agent is introduced into the azo-coupling reaction with interferon in an aqueous or aqueous-organic medium with a pH from 7.0 to 10.0 and e) the mixture of pegylation products is separated by ion-exchange chromatography to produce mono-interglylated interferon. A method of preparing an activated PEG agent is also provided. EFFECT: expansion of the spectrum of interferons with an increased circulation time in the bloodstream. |
| priorityDate | 2011-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 169.