| abstract |
The invention is directed to certain derivatives of {2- (alkyl) -3- [2- (5-fluoro-4-pyrimidinyl) hydrazino] -3-oxopropyl} hydroxyformamide, compositions containing them, the use of such compounds to inhibit the activity of bacterial peptide deformylase (PDF ) and in the treatment of bacterial infections. Specifically, the present invention is directed to compounds of formula (I), wherein R1, R2 and R3 are defined herein, and their pharmaceutically acceptable salts. The compounds of this invention are inhibitors of bacterial peptide deformylase and may be useful in the treatment of bacterial infections. |