| abstract |
According to the invention, isolated monoclonal antibodies that specifically bind mesothelin with high affinity, in particular human monoclonal antibodies, are provided. In a preferred embodiment, the antibodies bind human mesothelin. In some embodiments, antibodies can be internalized into cells expressing mesothelin, or may act as mediators of antigen-dependent cellular cytotoxicity. Further, according to the invention, antibodies to mesothelin have been proposed, which methods inhibit CA125 ovarian cancer antigen. Also provided are nucleic acid molecules encoding antibodies of the invention, expression vectors, host cells, and methods for expressing antibodies of the invention. Further proposed are conjugates of antibody and partner molecules, bispietic molecules, and pharmaceutical compositions comprising antibodies of the invention. The invention also provides methods for detecting mesothelin, as well as methods for treating malignant tumors, such as mesothelioma, pancreatic malignant tumors, and ovarian malignant tumors, using the anti-mesothelin antibody of the invention. |