| abstract |
The present invention relates to methods for producing compounds inhibiting the enzyme 11-β-hydroxysteroid dehydrogenase type 1 (11-β GDM1). One of these methods includes: (a) contacting a compound of formula (II) with a chiral base, a deprotonating agent and an alkylating agent R-LG, (b) contacting the product of step (a) with an acid to form a salt, and (c ) the interaction of the obtained salt with a base, with the formation of the compounds of formula (I) where Z, R, R and R are defined in this application. |