| abstract |
The invention relates to compounds with the following formulas or their pharmaceutically acceptable salts, as well as pharmaceutical compositions containing these compounds and a pharmaceutically acceptable diluent or carrier. The compounds of the present invention are useful for treating general inflammation, arthritis, rheumatism, osteoarthritis, inflammatory bowel diseases, inflammatory eye diseases, inflammations or unstable bladder diseases, psoriasis, skin diseases with inflammatory elements, chronic inflammatory diseases including, but not limited to, autoimmune diseases such as systemic lupus erythematosus (SLE), kinesthesia, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytope Sanitary purpura, Charcot-Vulpian disease, Sjogren syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, cancers mediated, dependent or associated with p110δ activity, which include, but are not limited to, leukemias, such as acute leukemia, myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative diseases (MPD), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukemia (T-ALL), B-cell lymphoblastic leukemia uw (B-ALL), non-Hodgkin's lymphoma (NHL), B-cell lymphoma and solid tumors such as breast cancer. |