| abstract |
The invention relates to compounds of formula (I) and their salts, where m is 1 and n is 0 or 1; Q, V and W are independently —N = or —C =; B denotes a divalent radical selected from (B2) and (B6), where the bond marked * is linked to a ring containing Q, V and W; A represents a cyclohexyl or phenyl ring; - [Linker] - refers to a bond, -CH-NH-CH- or -NH-CH-; Z is a radical of the formula RRCHNH- or RRCHNH-CH-, where R is a carboxyl group (-COOH) or an ester group selected from the group of ester groups of the formula - (C = O) OR, where R is RRCH-, where R and R together with a carbon atom, to which they are attached, form a monocyclic carbocyclic ring of 3-7 atoms in the ring; R denotes the side chain of a natural or non-natural alpha amino acid, the side chain of a non-natural alpha amino acid selected from phenyl, cyclohexylmethyl, cyclohexyl, pyridin-3-ylmethyl, tert-butoxymethyl, tert-butyl, 1-benzylthio-1-methylethyl, 1-methylthio -1-methylethyl, 1-mercapto-1-methylethyl and phenylethyl. The compounds of the invention are histone deacetylase inhibitors and are useful in the treatment of diseases associated with cell proliferation, including cancer. |