| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cacb803fee63ec6a5334e67e94453ced |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 |
| filingDate |
2007-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20bbf4cd8d487d76326d1df5f4ebe468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e91ebb5f7ba76a90195205b7196167c3 |
| publicationDate |
2012-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-016399-B1 |
| titleOfInvention |
METHOD OF SYNTHESIS OF SUBSTITUTED HYDROXYMETHYLPHENOLS |
| abstract |
The present invention describes a method for producing 2- (3-diisopropylamino-1-phenylpropyl) -4- (hydroxymethyl) phenol or its phenolic monoesters or their salts, comprising the following steps: a) reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent; b) if necessary, lowering the temperature of the Grignard reagent to a level below the temperature in stage a); c) reacting the resulting Grignard reagent with an excess of carbonate in a solvent to obtain a compound of formula (III) wherein A is C — C alkyl; and d) the subsequent recovery of the compounds of formula (III) in the usual way to obtain the target product. |
| priorityDate |
2006-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |