| abstract |
The invention provides compounds of the formula or their enantiomer, or a pharmaceutically acceptable salt, where R is selected from the group consisting of fluorine and chlorine; R 'is selected from the group consisting of hydrogen, bromine, iodine, ethynyl, amino, and methanesulfonamido; R is selected from the group consisting of methyl, methoxycarbonylmethyl, 2-dimethylaminoethyl, 2-hydroxyethoxy, 2,3-dihydroxypropoxy, benzyl, (C) alkyl, substituted with 1 or 2 hydroxy groups; and R is selected from the group consisting of hydrogen, methyl, fluorine and chlorine for use with MEK (I). Also provided are pharmaceutical compositions containing such compounds, and methods of using said compounds. |