| abstract |
Selected human monoclonal antibodies that specifically bind to IL-15 (for example, human IL-15), as well as corresponding compositions based on similar antibodies and molecules, are described. Human antibodies can be obtained in a transfectome or non-human transgenic animal, for example in a transgenic mouse, capable of forming a variety of isotypes of human monoclonal antibodies by recombination of V-D-J and switching isotypes. Also presented are pharmaceutical compositions containing human antibodies, transgenic non-human animals, and hybridomas that produce human antibodies, as well as methods of therapy and diagnosis using human antibodies. |