| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1585900ff4a8f76b4c5c4e6fb605a749 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-74 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09 |
| filingDate |
2007-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1e4b6a55c32b784c698ec36ead0a439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04f1bc11339b58ca59949521bf614082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_151d61a83129205dc9e241770ff74bdc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08327c11b75dfb7f4e52799a93906863 |
| publicationDate |
2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-015836-B1 |
| titleOfInvention |
METHOD FOR OBTAINING 6- [3- (1-ADAMANTHYL) -4-METHOXYPHENYL] -2-NAPTOIC ACID |
| abstract |
The method of obtaining 6- [3- (1-adamantyl) -4-methoxyphenyl] -2-naphthoic acid from 2- (1-adamantyl) -4-bromoanisole, based on the conversion of 2- (1-adamantyl) -4-bromoanisole in Grignard reagent using metallic magnesium, anhydrous lithium chloride and dibromoethane, followed by transmetallization with borates of up to 3- (adamantyl) -4-methoxyphenylboronic acid, which is converted into 6- [3- (1-adamantyl) -4-methoxyphenyl esters] -2-naphthoic acid by the reaction of cross-combination of Suzuki-Miyaura with alkyl-6-halogenaphthoate, catalyzed by Pd (0) or Pd / phosphine ligand E and followed by alkaline hydrolysis of these esters in ethylene glycol or 1,2-propanediol to obtain 6- [3- (1-adamantyl) -4-methoxyphenyl] -2-naphthoic acid. |
| priorityDate |
2006-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |