| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9a36328274867f46f8fc1fb9c868703 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
| filingDate |
2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f6a26222ffd3ecd08f1b284835cf137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e86c99e147da09de2d1b940f86bbd5f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf11d0863974cda74406f56567409256
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66e6af8b6a7ee4e4b895960bb804a7dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e1b2713eb32252907cc3d98c19f6231
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f6ec83acb75458a2eaf605396f5f9a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01f49fe6029424c7d37c69fb45df8d6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6de0b4b8caccb3bb3de41b36eb9b433
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dd676ae2c4a3da75b6c832bae99fafa |
| publicationDate |
2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-015828-B1 |
| titleOfInvention |
METHOD FOR OBTAINING BLACKXETIN AND NEW KEY INTERMEDIATES FOR ITS APPLICATION |
| abstract |
The present invention relates to a process for the preparation of duloxetine ((S)-(+)-N-methyl-N-(3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine) of formula (I) and its pharmaceutically acceptable salts, comprising the steps of a) cleaving racemic 3-(N-methyl-N-benzylamino)-1-(2-thienyl)-1-propanol of formula (II) with a D-phenylglycine derivative to form a compound of formula (IV) and b) reacting (S )-3-(N-methyl-N-benzylamino)-1-(2-thienyl)-1-propanol of formula (IV) with 1-fluoronaphthalene to form (S)-N-methyl-N-benzyl-3-( 1-naphthalenyloxy)-3-(2-thienyl)propanamine of formula (V), reacting the resulting compound of formula (V) with 1-chloroethyl chloroformate to form duloxetine of formula (I) and, if required, converting the resulting duloxetine of formula (I) to its acid addition salt. |
| priorityDate |
2006-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |