http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-015557-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d988170872411e760e4c452fbea9dcde |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-10 |
| filingDate | 2006-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70377a95f164bd92da6f1763baf5cff0 |
| publicationDate | 2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-015557-B1 |
| titleOfInvention | METHOD OF OBTAINING HYDROCHLORIDE 1 (10) β-EPOXI-13-DIMETHYLAMINO-5,7α, 6,11β (H) -GVAY-3 (4) -EN-6,12-OLID, LYOPHYLIZED ANTI-tumoral agent "ARGLABIN" |
| abstract | The invention relates to a technology for the production of new drugs from plant materials, namely the anti-tumor drug "Arglabin", and can be used for chemotherapy of malignant tumors and expanding the range of immunomodulating agents. The objective and technical result of the invention is to develop a method for producing an antitumor agent based on natural sesquiterpene lactone, which eliminates the use of toxic reagents and provides a significant reduction in the duration of the process. The specified technical result is provided in a method for producing 1 (10) β-epoxy-13-dimethylamino-5,7α, 6,11β (H) -guay-3 (4) -en-6,12-olide hydrochloride, lyophilized, antitumor agent possessing radiosensitizing and immunomodulating properties, including extraction of plant materials - smooth wormwood Artemisia glabella Kar. et. temperature 60 ± 0.5 ° C, the separation of the resin into individual components is carried out by preparative fluid chromatography using reverse phase C, in the synthesis of dimethylaminoarg hydrochloride Technical Abin Arglabin dissolved in acetonitrile at a weight ratio of 1:10 with the addition of dimethylammonium dimethylcarbamate in a molar ratio of 1: 1.62. |
| priorityDate | 2006-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 180.