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filingDate 2004-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21919fca0cb6b6112cc5407051b50768
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publicationDate 2011-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EA-015349-B1
titleOfInvention SOLID, DIFFERENT, ORAL, PHARMACEUTICAL, DOSING, FORMING SAQUINAVIRMEZILATE AND METHOD FOR ITS MANUFACTURE
abstract The invention describes a solid, single oral pharmaceutical dosage form of saquinavirmesylate containing a core and a core containing element selected from a film coating of a tablet, capsule or coating of an oval tablet, comprising from about 60 to about 80% of micronized saquinavirmesylate based on mesylate, from about 4 to about 8% of a pharmaceutically acceptable water-soluble binder, a pharmaceutically acceptable substance that provides disintegration, selected from the group comprising the sodium salt of cr carmellose and crospovidone, and a pharmaceutically acceptable carrier with a particle size of from about 30 to about 200 microns, where all percentages are based on the weight of the core of the pharmaceutical dosage form, where the core of the pharmaceutical dosage form includes a mixture of granulate and an additional component of granulate , in which the specified granulate includes micronized saquinavirmesylate, a binder, a carrier and a disintegrating agent, and an additional component of the granulate comprises a disintegrant, wherein the ratio of the disintegrant contained in the granulate, to the amount of the disintegrant contained in the additional component of the granulate is from about 3: 1 to about 1: 1.
priorityDate 2003-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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