| abstract |
This invention provides compositions related to antibodies against IGF-1R, and methods obtained by these antibodies. In some embodiments, the invention relates to fully human, humanized or chimeric antibodies against IGF-1R or human antibodies against IGF-1R, which bind to human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies and IGF-1R-binding polypeptides, including such fragments. Other variants offer nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells containing such polynucleotides, methods for producing such antibodies, fragments and derivatives of antibodies and polypeptides, and methods of using such antibodies, fragments and derivatives of antibodies and polypeptides, including methods treating or diagnosing subjects with disorders or conditions associated with IGF-1R. |