| abstract |
A method for the preparation of polymeric conjugates of N- (2-hydroxypropyl) methacrylamide and methacryloylamino acryd hydrazone doxorubicin with a controlled pH release of a drug, comprising the following three stages of the synthesis: (a) preparation of monomeric methacryloylaminoacylhydrazine, where the aminoacyl is derived from an amino acid, where the aminoacyl is derived from the amino acid, and the amino acid is derived from an amino acid. an amino acid or derivative of these substances, and subsequent hydrazinolysis, (b) the synthesis of a polymer precursor by direct copolymer tion N- (2-hydroxypropyl) methacrylamide and methacryloylaminoacylhydrazine and (c) binding and doxorubicin polymeric precursor by reacting the latter with doxorubicin hydrochloride. |