| abstract |
The invention provides compounds of general formula (I) wherein n is 1 or 2; R and R are independently selected from hydrogen or (C-C) alkyl; R and R are independently hydrogen; R is hydrogen or (C-C) alkyl and Ar is optionally substituted aryl or heteroaryl or cycloalkyl; and Ar is optionally substituted aryl. Such compounds are glycine transporter-1 (GlyT-1) inhibitors and are useful in treating diseases that can be treated by inhibiting GlyT-1, such as schizophrenia, impaired cognitive functions associated with schizophrenia, anxiety or depression. Pharmaceutical compositions containing such compounds and methods for preparing these compounds are also provided. |