abstract |
Pyrimidone derivative represented by formula (I), or its salt, its solvate or its hydrate, where Y is two hydrogen atoms, an oxygen atom; Z is a bond, an oxygen atom, a nitrogen atom substituted by a hydrogen atom or a C1-6 alkyl group; R1 is a 2, 3, or 4-pyridine ring or a 2, 4, or 5-pyrimidine ring, wherein the ring is optionally substituted; R2 is a benzene ring or naphthalene ring; these rings are optionally substituted; R3 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; R4 represents a hydrogen atom; R5 represents a hydrogen atom; R6 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; R7 represents a hydrogen atom or a C1-6 alkyl group; n is from 0 to 3; m is from 0 to 1; o ranges from 0 to 2. The invention also relates to a medicament comprising said derivative or a salt thereof as an active ingredient, which is used for prophylactic and / or therapeutic treatment of a disease caused by the abnormal activity of GSK3β, such as Alzheimer's disease. |