| titleOfInvention |
ANTIBODIES TO INTERLEUKIN 15 (VARIANTS), PROCESS FOR THEIR PREPARATION, immunoconjugates BASED THEREON, hybridoma, transfectoma, transgenic animal expression vector (VARIANTS) AND NUCLEIC ACIDS FOR PRODUCTION THEREOF, METHOD FOR TREATMENT (VARIANTS) AND A METHOD FOR DIAGNOSIS diseases mediated by IL-15 , METHOD FOR INHIBITING INDUCED TNF-α PRODUCTION IL-15 AND METHOD FOR INHIBITING INDUCED CELL PROLIFERATION |
| abstract |
Described isolated human monoclonal antibodies that specifically bind to IL-15 (for example, human IL-15), as well as the corresponding compositions based on these antibodies and molecules are described. Human antibodies can be obtained in a transfectome or non-human transgenic animal, for example in a transgenic mouse capable of generating multiple isotypes of human monoclonal antibodies by recombination of V-D-J and isotype switching. Also provided are pharmaceutical compositions comprising human antibodies, transgenic animals other than humans, and hybridomas that produce human antibodies, as well as methods of therapy and diagnosis using human antibodies. |