http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-014559-B1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
filingDate | 2006-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6aecb37ab42624e79da0ff6d874360dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73d787bedec60764090ed6c7c9a476d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_167cfb4fb94de5999006bb708ecc3c07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6afc01f6a039b40623a896bd08f65cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_144419bcaf577c9db2d0deb9e195a6b8 |
publicationDate | 2010-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EA-014559-B1 |
titleOfInvention | METHOD OF OBTAINING (S) -N-METHYL-3- (1-NAFTYLOXY) -3- (2-THIENYL) PROPYLAMINE HYDROCHLORIDE (DULOXETHINE) |
abstract | The method of obtaining (S) -N-methyl-3- (1-naphthyloxy) -3- (2-thienyl) propylamine of formula (I) and its pharmaceutically acceptable salts, including: a) interaction (RS) -N, N-dimethyl -3- (1-naphthyloxy) -3- (2-thienyl) propylamine of formula (III) with optically active D-tartaric acid or an acid salt, which is a derivative of D-tartaric acid, to form a mixture of diastereoisomeric salts of N, N-dimethyl- 3- (1-naphthyloxy) -3- (2-thienyl) propylamine and D-tartaric acid (2: 1); b) isolation of the salt (S) -N, N-dimethyl-3- (1-naphthyloxy) -3- (2-thienyl) propylamine / D-tartrate (2: 1) from a mixture of diastereoisomeric salts in an organic solvent, water or their mixtures and isolation of (S) -N, N-dimethyl-3- (1-naphthyloxy) -3- (2-thienyl) propylamine of formula (S) - (III) by the action of an inorganic or organic base; c) demethylation of (S) -N, N-dimethyl-3- (1-naphthyloxy) -3- (2-thienyl) propylamine by the action of an alkylated derivative of chloroform of the formula ClCOOR (R = C-C-alkyl, or CC-aryl, or alkylaryl), in particular phenyl, ethyl or methyl chloroformate; and d) hydrolytic release of duloxetine base of formula (I) and the possible transformation of the base into salt with an appropriate acid or salt of a weak base, and in stage (a) D-tartaric acid is used as an optically active substance in a molar ratio of 1: 2 relative to the substance of formula (III), or acidic alkali metal D-tartrate, or ammonium tartrate, or, alternatively, alkylammonium tartrate of formula (IV) in a 1: 1 molar ratio relative to the substance of formula (III). |
priorityDate | 2006-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.