| abstract |
This invention relates to new substituted tetracyclic tetrahydrofuran derivatives containing a side chain represented by a cyclic amine having binding affinity for dopamine receptors, in particular D-dopamine receptors, serotonin receptors, in particular 5-HT and 5-HT receptors, and pharmaceutical compositions containing the compounds of this invention, their use as a medicine, in particular for the prevention and / or treatment of a number of psychiatric and neurological disorders tv, in particular certain psychotic, cardiovascular and gastrokinetic disorders, and processes for their preparation. The compounds of this invention can be represented by general formula (I) and also include their pharmaceutically acceptable acid or base addition salt, their N-oxide form or their quaternary ammonium salt, where all substituents are as defined in claim 1. |