| abstract |
Cells used for the production of antibody compositions are described, for example, antibodies having high antibody-dependent cellular cytotoxic activity, useful in various diseases, antibody fragments and fusion proteins having an antibody Fc region; a method for producing an antibody composition using such cells; antibody compositions and their use. In the above antibody compositions, the proportion of fucose-free carbohydrate chains bound to N-acetylglucosamine at the reducing end of the carbohydrate chain in the total number of complex carbohydrate chains linked via the N-glycosidic linkage to the Fc region is 20% or more. In addition, new GDP-mannose-4,6-dehydrogenase, GDP-keto-6-deoxymanannose-3,5-epimerase, 4-reductase, GDP-beta-L-fucosopyrophosphorylase, alpha-1,6-fucosyltransferase and DNA are described encoding these compounds. |