| abstract |
The invention relates to compounds represented by the formula (I), their optically active isomers, or their pharmaceutically acceptable salts, wherein R represents methyl in the said formula; R represents a hydrogen atom; R represents fluorine fluoride at position 3 of the pyridine ring; q is 1; R represents a group represented by formula (II), wherein A is (C — C) aryl or heterocycle; the meanings of R and R are given in the description and X represents oxygen or NH, which are tau protein kinase 1 inhibitors. The invention also relates to the use of said compounds for the manufacture of a medicament for the prophylaxis and / or treatment of a disease caused by hyperactivity of tau protein kinase 1, such as neurodegenerative diseases (e.g. Alzheimer's disease). |