| abstract |
This patent discloses a method for the separation of 4- [4- (dimethylamino) -1- (4'-fluorophenyl) -1-hydroxybutyl] -3- (hydroxymethyl) benzonitrile as a racemic or non-racemic mixture of enantiomers into individual enantiomers, comprising a stage of fractional crystallization 4 - [4- (dimethylamino) -1- (4'-fluorophenyl) -1-hydroxybutyl] -3- (hydroxymethyl) benzonitrile in the form of a salt with (+) - (S, S) - or (-) - (R, R) -enantiomer O, O'-di-p-toluene acid in the solvent system, including 1-propanol, ethanol or acetonitrile. |