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filingDate 2004-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c8951b6c22b814651548b0953dd5065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_776c37327141c4a5b459d09475771608
publicationDate 2009-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EA-012783-B1
titleOfInvention PHARMACEUTICAL COMPOSITION FOR CONTRACEPTION AND SUBSTITUTIONAL HORMONAL THERAPY
abstract The present invention relates to slow-release estradiol-progesterone compositions that can be used in contraception and hormone replacement therapy. The compositions comprise molded particles of estradiol, which is in a hemicrystalline form, exhibiting a particularly low dissolution rate. Molded particles include estradiol mixed in a 1: 1 molar ratio with cholesterol and are intended to be administered in combination with progesterone. The slow release compositions of the present invention provide the dual benefits of a low dose estradiol composition with a low frequency administration regimen. The compositions may be administered parenterally once a month or less frequently.
priorityDate 2003-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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