| abstract |
The present invention describes antibodies and antibody fragments that bind antigens, synthetic polypeptides and analogs that selectively bind cellular CA 125 / 0772P polypeptides in comparison with cultured CA 125 / 0772P polypeptides. The present invention also describes methods for preventing the occurrence, control, treatment and reduction of the intensity of the manifestation of one or more symptoms caused by diseases associated with CA 125 / 0772P. In particular, the present invention encompasses methods for preventing the onset, controlling, treating, and reducing the intensity of the manifestation of one or more symptoms caused by diseases associated with cell proliferation, such as cancer (for example, ovarian cancer). Further, the present invention describes methods for diagnosing diseases associated with CA 125 / 0772P, or susceptibility to such diseases, as well as methods for identifying antibodies selectively binding cellular CA 125 / 0772R polypeptides in comparison with cultured CA 125 / 0772P polypeptides. |