abstract |
A humanized immunoglobulin that specifically binds to an amyloid beta peptide (Aβ) or an antigen binding fragment thereof is described, comprising: i) a light chain containing the hypervariable regions (CDRs) of the immunoglobulin 10D5 light chain variable region sequence represented as SEQ ID NO: 14, and frame sections of the variable region of the light chain of a human acceptor immunoglobulin, and ii) a heavy chain containing hypervariable regions (CDR) of the sequence of the variable region of the heavy chain of immunoglobulin 10D5, presented as SEQ ID NO: 16, and frame regions of the variable region of the heavy chain of a human acceptor immunoglobulin. Immunoglobulin is intended for the prevention or treatment of amyloidogenic diseases. |