| abstract |
The invention relates to a novel process for the preparation of N- (trans-4-isopropylcyclohexylcarbonyl) -D-phenylalanine (nateglinide) in the "H" crystalline form. The method consists in boiling in an alkane, preferably in n-hexane or n-heptane, of the starting material, which is another crystalline modification of nateglinide having a low boiling point, or boiling a mixture of such modifications until the product is obtained in a stable crystalline "H" form. |