| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7946ec4f3ab0ccdf6d369bf5079567ea |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate |
2005-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10e788608edcb57ea4fc733d379ac13f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a861e5945646db8b327620c99cf78115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ea3e6a31239f058e7a724b21a7c5858
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c08d74fc9968c7939557f97cf7ad5ae |
| publicationDate |
2008-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-010374-B1 |
| titleOfInvention |
POLYPEPTIDES WITH IMPROVED EXPRESSION |
| abstract |
A composite polypeptide is provided comprising a parent polypeptide and an expression enhancing domain (EED); said EED contains the first and second amino acid residues of cysteine Cys1 and Cys2, wherein Cys1 is located closer to the N-terminus of the compound polypeptide molecule than Cys2, and Cys1 and Cys2 are separated by a polypeptide linker that is free of cysteine and proline; determines a length sufficient to allow Cys1 and Cys2 to form an intramolecular disulfide bond with each other; has a flexible polypeptide conformation substantially free of a secondary polypeptide structure in an aqueous solution; moreover, at least one of the residues Cys1 and Cys2 is derivatized using the derivatizing component. |
| priorityDate |
2004-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |